One character, played by an able-bodied person, has had her limbs and internals replaced with electronic parts, so she's kind of a cyborg. However, its played as more of a superpower than a disability, and it's not really in the spirit of the question, so I voted no.
There is a very brief series of underwater scenes after the characters get teleported in the sharknado for the first time and land off the coast of Australia.
No, but if you dont like large scale violence, there are many natural disasters and widespread destruction, including tornadoes and a tsunami-like mass of sharks.