there are spider-like enemies that appear in the caves during sections 4-1 and 4-2.
the boss of section 5-1 may trigger some arachnophobia related anxiety as it appears to be a mutated crab or spider-like creature (although opinions might vary so i'm not sure).
there are occasionally non hostile spiders in the environment on floors or walls.
occasionally in crates or vases you break open you might come across snakes which aren't necessarily enemies but they can attack you for a small amount of damage.
Kind of. There is a boss in chapter 5 that is under control by the main villian who is connected to one of the playable leads. Not a supernatural/ religious/demonic possession though( They are being controlled with a chest device, get of them to defeat them btw). They are not in full control of their actions but still aware of what they are doing. If you played the game you know what I'm talking about. Kind of a possession, but not Exorcist style though
It should be noted that this game revolves around the player character, a white man, going to Africa on a mission and killing several black enemies in a small village.