There is a mission that takes place in an underground dog fighting arena that has one body in it. Enemy patrol dogs are also in other missions or locations, but they can almost always be avoided or stunned without killing them. Friendly dogs appear in the map, and it is possible to accidentally injure them while driving, BUT you can also pet them.
SPOILERS
One mission is centered around the kidnapping and subsequent murder of a main character. An unskippable cutscene shows said character being attacked and dragged into a car from the point of view of a security camera.
In one mission, the group gets high on psychedelic mushrooms. For a short while, you see through the perspective of the main character, with bright colors and hallucinations.
There is a mission where you enter a dogfighting ring, there are enemy dogs which can detect the player, meaning it's helpful to the player to knock out/taze/shoot them
There is one notable trans character who is never misgendered. However, she mentions that, after she made some disparaging comments about a group based off of the Church of Scientology, that group leaked photos of her reassignment surgery.