Heavy amounts. It can be lessened in the settings, but this game is absolutely not safe for photosensitive people. There are multiple warnings about this.
The concept of virginity is mentioned and a character can be seen as drawn to be provocative, but there's no explicit sexual content or objectification.
Heavy amounts. Guns are common weapons and are used by the protagonist and enemies. Can technically be avoided but there's a few unskippable sections and cutscenes in which guns are used.