SHORT ANSWER NO, BUT the longer answer is a little more nuanced. At the end of the movie, all of the neighborhood sex workers are hanging out in the back of a van. They are all cis women except for one AMAB sex worker wearing a red slip. Technically, this is done non-judgmentally as the character is every much as an accepted part of the group as everyone else, and they are not presented in a punchline manner. Very unfortunately, however, this sex worker is played by none other than Chris Noth who is kind of an awful person who says a lot of extremely awful things, and it is impossible to see him like that without instantaneously knowing that he made all sorts of horrible "man in a dress jokes" all over the set before and after shooting the scene.
The main character puts a gun to her head (that she was told isn't loaded but which she doesn't confirm) and pretends to kill herself. She also makes a friend swear to shoot her with the same gun if her life plans don't work out and makes a number of other half kidding half serious suicidal statements.
The roommate of one of the main character's romantic interests drinks a lot, but isn't on screen much, and the main character is scene drinking in a few scenes, but it isn't especially to excess or painted as a problem.
Yes, though not in the dating violence sense. The movie begins with the main female character flirting with a guy on a subway who follows her to see where she works so that he can run into her when she gets off work. Similarly, she pops up where she isn't necessarily wanted by guys she is flirting with, but who also don't necessarily totally mind that she showed up.
YES, twice. The main character (who has just been evicted) is molested in her sleep by a "creep" character (who is the roommate of someone she is interested in and spending the night with) fondling her with the clear goal of having sex with her if she doesn't wake up or fend him off. Later, another male character who is supposed to be a "nice guy" who is letting her stay with him also fleetingly touches her inappropriately in her sleep. In both cases, men are molesting a vulnerable homeless person who is dependent on a place to stay. It also ends with the main character in a sexually unsafe situation.