Humanity has advanced to great heights since it obtained the information technology known as "Mana." With that nearly magical power, problems like war, food shortages, and pollution have been eliminated. This age of peace and freedom, the Empress Angelese of the Misurugi Empire is a privileged girl with no disabilities. She learns, however, that she is a "Norma," a kind of human who cannot use Mana and are outcasts of society. Having lost everything, she is sent to an isolated island. There she meets other Normas who ride in humanoid weapons called Para-mails, protecting the world from dragons invaders from another dimension.
Sort of. Certain members of the main protagonist's family cause the deaths of other certain members of said family - and a few more instances where one member tries to kill another.
There is no antisemitism in this anime, although the setting does have government-enforced racism and what's basically a prison where the victims of this are forced into labor, far away from everyone else.
The main antagonist has been shown to be unfaithful, but it isn't focused on amidst the many, many other atrocities they commit. The main protagonist also shows affection to multiple characters, although it isn't clear if it's cheating or polyamory.
Several later episodes showcase people being possessed. Typically background characters are victimized by this, but a main protagonist and a minor character both get possessed, too.
Sort of. One character is stated to have some kind of drug used on them, although it's not recreationally and it's not focused on for more than a few seconds at a time. It doesn't seem to be an addiction.
The anime features a mech that can transform into a fighter-jet like form. These mechs also crash several times during the course of the anime, although there is only ever one pilot in them at a time. (Many times they survive this)
Dragons dying happens almost every episode, sometimes in great numbers. While they are more than capable of defending themselves, you're going to see a lot of dragon death in this anime. There are many instances of people dying because of a dragon, too, although not as often.