One character mentions momentarily a worry about becoming fat (not in a joking way and not more than a mention) during a phone call, but that's about it.
The one character makes an offhand comment about having OCD in what seems like a joking manner. And a lot of "insane" "crazy" etc. in a derogatory and offhand manner.
Only mentioned, not shown. Also one character who is technically a parent (his grown up kids are only mentioned not shown) appears to die in a scene, it's not reality.
One character's kid had cancer and it's discussed extensively but she's fine now. And the main character works in a clinic focusing on alternative therapies for cancer patients so it's mentioned and a couple of the patients are shown momentarily in a couple of scenes.
It's not specifically framed as alcohol abuse, but there is a lot of drinking and one character who talks about how she shouldn't drink like that and then continues to drink.