Many. For example, in one episode a character literally "beats a dead horse".

Yes, in a few episodes a dog is killed. For example, there are a few dogs that kill themselves because they are owned by Paris Hilton (Stupid Spoiled Wh*** Video Playset). I also believe a dog is hit by a car in Ike's Wee Wee.

In the pandemic special a pangolin is killed with a flame thrower

In the pandemic special a bat and pangolin are... sexually assaulted.

In one episode Stans dog Sparky was going to fight with another wild one, but then Sparky just rape the other dog before attack or get attacked

Remember the beating the dead horse joke?

The action is not shown on-screen, but the aftermath is-- in Paris Hilton's scrapbook, multiple pets are shown to have committed various acts of suicide. There is at least one cat among them. (also in a more realistic art style than usual.)

Cartman slays a dragon in a flash back he has.

Yes, in the episode "Red Hot Catholic Love" there is a queen spider in the Catholic church.

Many snakes are seen in the series, but the most notable is “Crippled Summer,” where Nathan tries to assassinate Jimmy with a black mamba.

yes, stan marsh when diagnosed with depression goes to alcohol as a "coping mechanism" for him to stop seeing everything as shit.

Yes, in "Hummels & Heroin" many people are shown to overdose. In "Quest for Ratings" the boys drink a bunch of cough syrup. In Season 22 Randy opens a weed farm. In "Towelie," "A Million Little Fibers," and "Crippled Summer" the character Towelie is shown to abuse marijuana and drugs. In "The Poor Kid" and "Lil' Crime Stoppers" meth labs are shown. In "Ike's Wee Wee" the counselor uses marijuana and possibly other drugs. In "Timmy 2000" drugs are also abused. In "My Future Self n' Me" drugs are mentioned. In "Medicinal Friend Chicken" marijuana is used. I may have missed a few episodes.

At some point Stan becomes an alcoholic

Cutting in mentioned and I believe shown in the episode "Goth Kids 3: Dawn of the Posers."

Yes, in the episode "Pre-School" the pre-school teacher gets burned alive twice. In "Spontaneous Combustion" many characters spontaneously combust.

Cartman drives someone to cannibalism.

Justin Bieber's head is squashed in the episode C**n vs. C**n and Friends"

Osama Bin Laden’s teeth are damaged and fall out in “Osama Bin Laden Has Farty Pants”. It is played in a cartoon-parody style.

Kenny in "Chinpokomon" has a seizure while playing a video game and is unresponsive for most of the episode until he dies.

A turkey attack kenny and rip the eye

In the episode Reverse Cowgirl Clyde's mom is killed by leaving the toilet seat up.

Eric, Stan, Kyle (I dont know if Kenny was still alive) were kidnapped by Barbara Streissand the episode is call Mecha-Streissand

One of the main children, Kenny, dies in many episodes (especially the older ones), usually graphically. He always comes back though.

Chef became a stripper for to pay a dept and one those people is Kyles mom, (she is married

In “1%,” Cartman stages a murder mystery with his toys, leading to all of them being destroyed.

Multiple jumpscares throughout series

In dead celebrities Ike sees ghosts

Cartman eats Kenny's ashes by accident and gets possessed in "A Ladder to Heaven" which kicks off a mild subplot in the latter half of Season 6. The Devil possesses Stan near the end of "Freemium Isn't Free."

Almost every scene about Canada (especially involving Terrence and Philip) has a fart joke in it.

In the beginning episodes, every time Wendy talks to Stan he vomits on screen.

In “Tsst,” Supernanny is sent to a mental institution.

A character with diabetes is shown giving himself an insulin shot.

In "Medicinal Fried Chicken" and in "Stanely's Cup"

Cartman constantly gaslights everyone in his life

"The Hobbit" is about girls photoshopping their pictures to look prettier.

Tweek is almost always anxious

The following is a list of episodes in which suicide is committed: "Cash For Gold" "Butter's Very Own Episode" (attempted) "Night of the Living Homeless" Super Best Friends" "Cartman's Mom is Still a Dirty Sl*t" C**n vs. C**n & Friends" "Cartman Sucks" "Stupid Spoiled Wh*** Video Playset" "Britney's New Look" "Pinewood Derby" "Death" I may have missed a few episodes, so please read up on any you plan to watch if you need to.

There is a small scene in dead kids where bullets are everywhere

Not a regular thing in the show itself but the "Pandemic" episodes have lots of very shaky cam scenes, so if it's something that makes you uncomfortable I'd recommand not watching them

One episode, “Kenny Dies,” features Cartman collecting a stash of aborted fetuses for stem cell research. “Woodland Critter Christmas” shows Stan teaching puma cubs how to perform abortions.

Kenny's mom has given birth at the end of "Cartman Joins NAMBLA" and goes into labor at the end of "C**n vs C**n and Friends." A porcupine gives birth in "Woodland Christmas Critters."

Hens were assaulted by the chickenlover, and CArtman was assaulted by many people

Sex jokes are frequent, along with nudity (especially bare bottoms).

Cartman admits to fooling around with his cousin in one episode.

"Mr. Garrison's Fancy New V****a" portrays transitioning as an impulse or a trend. The character does realize they weren't actually a trans woman several seasons later, but is misgendered in several episodes while they are presenting as a woman. A similar situation happens in "The Cissy" where Cartman pretend to be a trans girl to use the bathroom, but again it's hard to say because Cartman isn't actually trans, but the language used to discredit him might still upset some people. "Board Girls" has a trans woman character (or a man pretending to be a trans woman, it's never made quite clear) who is very masculine and many characters refer to her as "him" but quickly correct themselves. However, she is still essentially a caricature used to poke fun at the issue of trans women in sports. Other episodes misgender characters who aren't trans, such as Cartman calling Kyle a girl in "Super Hard PC-ness."

If this is triggers you in any way, skip the episode "Cartman Sucks."

Cartman is a neo-nazi, despite only being 10 or 11. All major religeons are made fun of in some way, although it's rather equal-opportunity about it.

Due to the many, many people who pass in South Park and the poor representation within the series, no, the black guy doesn't go first. But several black characters are killed at certain points in the series, most notably Chef.

Cartman is repeatedly called a f****s and variants thereof.

R****d and its variants get thrown around a lot and one episode has a disabled character defend his right to say it. Same with "cr*ppled." Though there are disabled characters who exist outside of being jokes like Jimmy and Nathan, a lot of jokes are made at their expense. Generally a lot of casual ableism that's to be expected if you know how South Park operates.

There’s an entire episode surrounding conversion therapy and lgbtq suicide

Antisemitism is present throughout the series, in most if not all episodes.

It's complicated. Most episodes depict Santa as existing in the real world and people interact with him, but "Imaginationland" portrays him as a figure of imagination. "Crack Baby Athletic Association" has a subplot that follows the typical story of someone learning Santa isn't real, except instead of Santa it's the musician Slash.

Depends how dark your sense of humour is on most episodes. A few episodes do have depressing endings no matter how you look at it though.

In one episode Kenny's parents kill each other, although there is no continuity and they are later shown to both be alive.

A truck runs over Kenny in "Best Friends Forever. "Put It Down" has several very gory scenes of children being run over. There's more occasions across the series.

Butters' parents. It's very stereotyped and is mostly shown as some kind of running gag but can still be very upsetting (he gets beaten in one episode, tho it's not shown, but you can hear it). Same goes for Tweek's parents, it isn't shown as much as Butters but still can be seen as abuse. (a few examples : not taking their son' anxiety seriously, making him work, giving him coffee with meth, pointing a gun at him to "teach a lesson")

A child hangs himself in “Cartman Sucks”, at a gay conversion program.

The fake Butters fell and die

In the episode "Super Best Friends." Also in "Butters' Very Own Episode" Butters' mom tries to drown him in the car.

There is a parody of WWZ

Yes, this is basically the theme of the episode "Grey Dawn," mocking how old people are terrible drivers. An ongoing gag in the later seasons shows Caitlyn Jenner hitting pedestrians. A few episodes where this happens are "Where My Country Gone?" and "Sponsored Content." In "Put It Down" many people run over children with their cars, if this counts as a car crash.

In the episode "Funnybot" Tyler Perry is buried alive