there are spider-like enemies that appear in the caves during sections 4-1 and 4-2. the boss of section 5-1 may trigger some arachnophobia related anxiety as it appears to be a mutated crab or spider-like creature (although opinions might vary so i'm not sure). there are occasionally non hostile spiders in the environment on floors or walls.
occasionally in crates or vases you break open you might come across snakes which aren't necessarily enemies but they can attack you for a small amount of damage.
It should be noted that this game revolves around the player character, a white man, going to Africa on a mission and killing several black enemies in a small village.