I'm not far into the manga and I haven't watched episode 1, but I made this page for everyone who wants to start it. Any help with the ratings, etc. from people who've read further than me would be appreciated.
There is definitely abuse and manipulation in the household as means of keeping the children from escaping/finding out the true nature of the orphanage, although this isn't really shown until the children are suspected. And a character gets her leg broken by the "mother" as to prevent her escape.
Characters are forced to become pregnant. It's not clarified weather this is through sex or artificial insemination, but it's likely intended to be the latter
small spoiler alert for season 1
in season 1, a character is seen to give up trying to escape grace field house and thinks it’ll be easier without them anyway and it’s a very emotional scene but not much of a sacrifice. another character later into season 1 attempts to light themself on fire to prevent anyone else from getting shipped out to the demons. they are saved shortly after though.
One of the caretakers is shown to speak to her baby doll as if it were alive, along with other eratic behavior that implies a mental break. She is the main violent antagonist of season 1
The caretakers have a traumatic past involving their children being taken. One of the caretakers seems to treat a baby doll in a way that implies a trauma coping mechanism
There's a flickering match in the season 1 intro and two lightning strikes in s1 ep2 at 9:20. Although the flashing is mild, a flickering fire covers the screen at s1 ep11 11:05-12:50, s1 ep11 17:10-17:35, s1 ep11 20:26-21:17, s1 ep12 0:00-0:07, s1 ep12 5:09-5:39, s1 ep12 12:50-13:00, and s1 ep12 19:55-20:07. I'm not sure about season 2.
Part of the story is that women are forced to give birth and then have their children taken away. We actually don't see the birth or baby being taken away, but we see a woman who has experienced this who has trauma from it
Its worth mentioning that although no one miscarries, women are forced to give birth and then have their children taken away from them. One woman this happened to has trauma from it, as she keep a toy baby and treats it as if it's real.