( slight spoilers ! )
I don’t have specific time stamps but
near the mid beginning, Charlie ( Brendan Fraser ) is given a meatball sandwich by Liz and he starts to retch & choke. It can be triggering.
Second, near the end of the movie after Charlie has a fight with his wife, he binges and then V during it. It was triggering and somewhat graphic
One is not seen on screen but it is described and mentions he took his own life because his parents didn’t accept him when he came out. One other LGBT person does die on screen. It is not graphic.
Without seeing to much of the movie it seems like there is portrayal of a obese person who eats to much and lazy/ mostly negative things about this person, which kinda mocks and blames people who Are both obese and overweight
The fat jokes are narratively used to make the deliverer of the jokes look like a bully rather than jokes for the audience to laugh with, but they are still vicious jokes
There is a character who talks about running away from his home and not knowing where to go. It is not clearly said that they're homeless but we can guess it.