In the beginning of the game, while the protagonist Ethan is putting his daughter to bed, an idle voice line of his states that his wife, Mia, is “scary when she’s angry”. [Spoilers Ahead] we do not know if Mia was always “scary when she’s angry”, or if this is a recent happening with Mother Miranda taking Mia’s place.
A lot of the backstory has to do with experimental mutation, so while it's not a "real" drug, innocent people are injected with fungal cells that ruin their lives.
A character has mutated, tentacle-like growths sprouting from one eye. A doll is stabbed in the eye and appears to bleed. Multiple key items are made to resemble eyeballs and are touched, prodded, taken apart, etc.
In the dungeons of Castle Dimitrescu, you can see various torture devices around, some of which can be inspected. There are logs kept detailing the victims and the sort of torture they endure. Also, the whole game is pretty much never ending torture for Ethan Winters.
House Beneviento has very thin corridors you must run through to get away from an enemy, all while in the pitch dark. When you encounter the enemy, you must hide in small places such as lockers or under a bed to avoid its attack.
You can find a corpse and a note implying suicide in one of the buildings in Moreau’s territory, but there are no weapons or clear visible wounds on the body.
During the fight with Miranda there is a sequence where you must shoot her quickly and repeatedly, and the gun causes the screen to flash as it is fired.
Not an actual abortion BUT there is a giant monster that resembles an aborted fetus. It chases you throughout the mansion and giggles and says "daddy" and it's absolutely the scariest thing in the entire game.
In House Beneviento, you can hear what is most likely childbirth. It is also implied that the dummy in the table in the same area is what gives birth to the giant baby.
Not outright, but it is worth noting that Karl Heisenberg is named after a Nazi-affiliated physicist, wears World War II German dog tags, and deals largely in human experimentation. The creator has since clarified that the character is not a Nazi due to these concerns.
Some may consider The Duke to be one, mostly due to his unfitted shirt, but there are never jokes at the expense of his weight, nor is it called to attention much at all
Lady Dimitrescu is highly objectified with her very low cut dress to show her almost impossible to miss cleavage. She also acts very seductive in the way she walks, talks and how she sucks Ethans blood. At the end of the scene, they hang Ethan up until he is above her, so you get the whole view of her cleavage, which is clearly done deliberately.
Near the beginning of the game you wake up on the ground near a crashed vehicle. There is no explosions or fire but the contents of the vehicle are scattered and a masked agent is presumably dead.
There is blood and gore pretty much all throughout the game. For example, [SPOILERS AHEAD ->] the main character Ethan Winters gets his hand cut off by one of the main antagonists named Lady Dimitrescu while trying to pull a lever to open a door. Earlier in the game, Ethan gets two of his fingers bitten off by a lycan.