in the show, as if now, there are lots of kissing scenes but no sex scenes. :)
In the book, in the last few pages of Volume 5, Nick and Charlie have (completely consensual, healthy, protected, and enthusiastic) sex. Only the upper part of them is shown, and it’s not pornographic.
one of the main characters is depicted in active recovery for self harm and an eating disorder- it is a major part of season 3 of the show, and is mentioned repeatedly in the comics