After the disastrous food storm in the first film, Flint and his friends are forced to leave the town. Flint accepts the invitation from his idol Chester V to join The Live Corp Company, which has been tasked to clean the island, and where the best inventors in the world create technologies for the betterment of mankind. When Flint discovers that his machine still operates and now creates mutant food beasts like living pickles, hungry tacodiles, shrimpanzees and apple pie-thons, he and his friends must return to save the world.
Well... there are "cheespiders" - spider-like living creatures in the form of giant burgers with French fry legs and countless eyes instead of sesame seeds.
(SPOILER AHEAD!) Chester V, who is the main antagonist of this film, is eaten by a giant living cheeseburger and dies. Although his body isn't shown, it's presumed that he's dead, because after the giant food eats Chester V, his orange jacket is spat out by the cheeseburger, which then deflates.
(SPOILER AHEAD!) Between 01:20:59 and 01:21:09, Chester V is eaten by a giant living cheeseburger. Before that, the creature spits out Chester V's orange jacket, which deflates, suggesting that Chester V has been eaten alive by the creature and is dead.