Sherlock Bones, an anthropomorphic dog from Wizard101, is said to have died in a dialogue exchange. It's strongly implied that this isn't the case, though.
Other anthropomorphic dogs are enemies that can be fought and defeated.
Anthropomorphic dogs can join your crew and fight alongside you, and some are fought as enemies.
Doglike pets can battle each other for rewards, though there's no chance of them getting injured or dying while doing this.
In Marleybone, Catbeard is arrested and when you see him in prison he looks VERY disturbed and disheveled, implying that he's been through some traumatic circumstances while behind bars. No overt torture is ever shown explicitly though.
In a side quest, a pirate around your character's age named Young Alex almost dies, but you save him. Other than that, no children are put in mortal danger.
The game has no official ending as of yet, but the story has an overall optimistic tone. The closest thing to a sad ending we get is when we see the aftermath of the war that the main character instigated in Marleybone, and it's clear that our actions have led to widespread and irreparable destruction.
In the beginning of the game, Ratbeard attempts to drug his crew to sleep to steal their share of Gunn's treasure, but he actually ends up killing them by mistake.
Snakes can be observed slithering around on several maps, especially in Cool Ranch. You will also meet Sister Snake there, a giant snake spirit, but she won't hurt you.
Although there are plenty of taverns and bars in every world, all in-game references to alcohol are censored and kid-friendly. Rum is "Yum", a fizzy purple beverage with magical properties that doesn't seem to make people drunk.
No real world religion, but the monkeys of Monquista practice a parody of Roman Catholicism and one side quest involves you answering a theological debate about bananas.
When they run out of hit points in battle, your companions will stagger and fall to the ground (some more melodramatically than others.) When your own character is knocked out, though, they'll just dizzily spin their head without fully fainting.
Upon arriving at Monquista, you are required to present a false identification that Captain Avery gives you. The gender of your I.D will always be the opposite of your character's gender (as well as being the wrong species), but the Majordomo lets you in anyway and doesn't question it.
Other anthropomorphic dogs are enemies that can be fought and defeated.