A mentally ill man in a small Texas town goes on a killing rampage and is fatally wounded by police. When doctors use an experimental serum to bring him back to life, the killer develops superhuman strength and the town sheriff must pursue him.
No dog dies on screen. There is a character who explains in detail to Chuck Norris's character about how he had a puppy when he was a kid and ended up killing it.
There aren't any overt fat jokes, but there is one character played by Flounder from Animal House whose entire presence is basically a joke that he's a blundering fat guy.