A character makes a fake gun with a fast food bag and robs a restaurant with it, threatening to shoot the employees. No one is in real danger, and the restaurant employees eventually learn this.
A character’s untreated alcoholism is a major plot point, initially played for laughs before getting suddenly Real and demonstrating the damage that alcoholism can cause to relationships and a person’s health.
Tammy right at the start of the movie hits a deer with her car, the deer after a moment gets up and runs away after hitting her with his hooves. It's also veru clearly a puppet deer.
A character says cruel things, but the scene is meant to illustrate how painful verbal abuse is and how out of line the character is. It is not intended to be funny.