the playable character can lose their eyes. if the character's mental health is low enough then they will claw out one of their eyes in an unavoidable sequence. it is not extremely explicit but still upsetting.
if the playable character's mood is low enough, the player is forced to complete a "minigame" where the character claws at their own skin. once this is triggered, there's no way to exit it without completing the action.
the player may be forced to amputate their character's limbs due to infection. the player must manually cut the limb off using a knife. the process is very upsetting.