There is a lot of body horror involving bugs, framed as a hallucination brought on by a demon. There is also a tapeworm infestation described in graphic detail.
It is speculated that a main character was assaulted. They never 100% confirm this, but that character recalls vague things that make the others believe it is true.
In the chapter "Party All The Time", a character remarks 'You guys are so queer". The two main characters often say "Dearly but not queerly" when expressing affection. Two straight characters are accused of being "homos". None of this is directed at LGBTQ characters (unsure if there even are any).