Wolf-or cougar-like alien wildlife must be exterminated or driven off to build in their territory. Uplifting might not kill viable targets, but it will ruin a perfectly good monkey and give it anxiety
"Aggressive observation" of pre-space age societies implies the abduction of its population for study. The Apocalypse DLC adds the ability to forcibly take population from empires you are at war with.
Weaponized. One extermination campaign you can commit is forced sterilization, which presumably involves forcible abortions in conjunction with mandatory vasectomies/hysterectomies.