One achievement requires sickening and killing Kim Kardashian’s dog. Also, the Shadow Plague can cause governments to begin euthanizing dogs and exterminating wolves.
A random piece of news claims that someone covered in essential oils has burst into flames. Also, this s9mehow occurs with a penguin at a zoo (who probably got into the water anyway...)
If the Insanity symptom is purchased/evolves, countries with atom bombs may start an outright nuclear war. There is also a random event wherein a nuclear power plant melts down.