George and Lenny travel through the Depression-era west working at odd jobs, hoping to make enough money to buy their own farm. George must always watch over his intellectually disabled friend, and keep him out of danger, both to himself and to others. After they take a new job at a ranch, Lenny gets into far more trouble than George can talk his way out of, leaving George to decide whether to help him, or leave him to his fate.
There is a big fight scene where Lennie gets punched in the face and then breaks Curlys hand. Curleys hand is bleeding and being bent while the other men try to restrain Lennie. This happens in the middle of the movie.
Towards the end of the movie, Lennie tries to restrain Curleys wife from screaming and he accidentally breaks her neck which causes her to die. Her corpse is shown multiple times after this