There's an audio diary where one of the subject's is being mind controlled and he has the subject break the dog's neck and you can hear the dog whining and the kid crying. It's pretty awful. I covered my ears and went lalala. If you don't want to hear it don't pick up the audio diary MIND CONTROL TEST-YI SUCHONG. I think there's also a part where you walk into a lab and there are a bunch of dead dogs in water tanks
Elizabeth uses tranquilizing needles. ADAM is harvested or delivered through needles. [Spoilers] A pair of Little Sisters harvest some ADAM from each other with a giant syringe.
You use plasmids which are essentially drugs, though all of Burial at Sea takes places before the Fall, so no one is quite crazy addicted yet. Liz also smokes at the beginning and I believe so do other Rapture residents