[Semi-spoilers] Sam, one of the main characters, is a dog, and he gets killed by the villain in Episode 3. However, he comes back as a zombie immediately after this, and continues acting basically the same as when he was alive. He's revived by the end of the episode.
Part of a puzzle requires tricking a vampire into smoking a cigarette, which is shown to have harmful effects (though this is because it contains garlic).
Leonard, who was tied up, gagged, and stuffed in Sam & Max's closet in the previous season, is shown to still be in this position. He manages to free himself during the epilogue (though he is still gagged)
Sam and Max are not supposed to be role models. They're basically all of the copaganda stereotypes (violent, not flowing the rules) played for humor. Misbehavior is identified as misbehavior, but it's still supposed to be funny. Make of that what you will.