There is a brief moment where the minds of a cisgender man and a cisgender woman are swapped. The players discuss what pronouns to use for one of the characters. That's about it.
As a game based on Call of Cthulhu, it's debatable. The players specifically state that a character with an odd voice is not mentally handicapped. Your mileage may vary, however, as it is a game where mental illness plays a major role.
"Xenonematodes," are creatures that appear in the first arc of the series, and resemble lampreys. Insects play a role in the "Bigfoot Underground" arc following Season 1.
EXTREMELY debatable. The player characters are cops, and ultimately blunder their way into saving the world. However, only one on-screen cop could be described as "morally upright." Most of the characters' heroics appear after their police department effectively disbands. The police are a largely-antagonistic force in the second season. Police are generally not viewed in a good light in the series.
Both mentally-ill and non-mentally-ill characters behave violently. One otherwise-upstanding character becomes violent in moments of extreme stress, which are referred to as "failed sanity rolls."
During a "boss battle," one character, a gay man, fails a luck roll and dies as a result. An alternate-universe copy of him is brought back to replace him.
There's a word that's bleeped out during a discussion of a minor character's mental competence. It's impossible to tell what the word is, but it could potentially be the r-slur.
No body dysmorphia occurred in Season 1, when this page was first created.
More recently in Season 2, however, Julius Summers develops a fear of/disconnect from his own face. This leads up to the beginnings of an interrupted self-mutilation attempt.
Nobody falls to their deaths in season 1, but a dead body does fall onto a car from a great height.
A possessed turtle falls to its death from a tower during season 2, and an animal with human-like intelligence falls to its death in a gorge.
Not intentionally, but Keith's dog Bean is stuck in a motel room during the first few parts of the series. He is shown escaping to safety in a side arc.