By way of extensive BBC archive footage, the programme charts his varied and ever-changing career - from the beginnings with The Yardbirds until he left to join the purist blues of John Mayall and the Bluesbreakers, to the dynamism and musical synchronisation with Ginger Baker and Jack Bruce, which produced the turbulent Cream, to Clapton's collaboration with Stevie Winwood that would spawn Blind Faith, to his brief sojourn in the Plastic Ono Band and his unforgettable contribution to Lennon's heroin hell tribute Cold Turkey, to his low-profile spell with rootsy US act Delaney and Bonnie, to the band he formed with Bobby Whitlock, Derek and the Dominoes, that produced one of the most famous unrequited love songs in Layla, and on to his successful solo career since then.