A character who is deeply depressed is shown barely conscious in a bathtub filled with (his) blood. Another character is horrified when he finds him and he is saved and brought to a hospital. This could be interpreted as an attempted suicide.
A character is shown in a bloody bathtub having cut his arms. We can't really see the wounds but there is a lot of blood and we can see the knife he used. We also see bloody bandages on his hands afterward.
There's a bright red light overlay when Aspen chases something around and in some flashbacks, characters smoke weed there are some colored lights on the walls but it's not really "flashing", more pulsating.
In the beginning, an old man dies and seems to have trouble breathing. Toward the end of the game, the same character is shown coughing a lot because of his illness.